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Oral squamous cell carcinoma in patients with Fanconi anemia: A case series
S. Goncalves1, Montgomery-Cranny J.1, Hunter K.D.2, A. Yousefpour3, L. Durham2, A.M. Hegarty1
1Department of Oral Medicine, Charles Clifford Dental Hospital, 76 Wellesley Road, S10 2SZ Sheffield, United Kingdom.
2Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, 19 Claremont Crescent, S10 2TA Sheffield, United Kingdom.
3Department of Oral and Maxillofacial Surgery, Charles Clifford Dental Hospital, 76 Wellesley Road, S10 2SZ Sheffield, United Kingdom.
4ENT Department, Royal Hallamshire Hospital, Glossop Road, S10 2JF Sheffield, United Kingdom.

Article ID: 100012Z07SG2016
doi:10.5348/Z07-2016-12-CS-10

Address correspondence to:
Dr. Anne Hegarty
Department of Oral Medicine, Charles Clifford Dental Hospital
Wellesley Road
Sheffield S102SZ

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How to cite this article:
Goncalves S, Montgomery-Cranny J, Hunter KD, Yousefpour A, Durham L, Hegarty AM. Oral squamous cell carcinoma in patients with Fanconi anemia: A case series. J Case Rep Images Dent 2016;6:42–46.


Abstract
Introduction: Fanconi anemia (FA) is a rare inherited disorder characterized by progressive bone marrow failure, congenital malformations and increased susceptibility to malignancies particularly acute myeloid leukemia and solid tumors such as head and neck, gastrointestinal and genitourinary tract carcinomas. The squamous cell carcinoma of the head and neck (HNSCC), known for its aggressive growth capacity, multifocal origin and propensity to metastasize is the most frequent solid tumor in these patients and is frequently associated with poor prognosis. An increased understanding of Fanconi anemia associated with malignancies is important in the clinical management of these patients and can elucidate the role of the disease in the development of malignant tumors namely head and neck squamous cell carcinoma.
Case Series: We describe three unrelated cases of patients with FA and multifocal head and neck squamous cell carcinomas.
Conclusion: This study highlights the susceptibility of patients with Fanconi anemia to malignant tumor development and reinforces the need for a routine head and neck cancer screening. The reader should understand the clinical features, implications of this association and the appropriate management of patients with Fanconi anemia.

Keywords: Anaemia, Carcinoma, Fanconi, Squamous


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Author Contributions:
S.S. Goncalves – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Montgomery-Cranny J. – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Hunter K.D. – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
A. Yousefpour – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
L. Durham – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
A.M. Hegarty – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
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The corresponding author is the guarantor of submission.
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Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 S. Goncalves et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.