Case Report


Low-grade intraductal carcinoma of the lower lip

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1 PhD, Research Fellow, Department of Pathology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6.627, Pampulha, Belo Horizonte, MG, Brazil

2 MD, PhD Student, Department of Oral Pathology, School of Dentistry, University of São Paulo, 2227 Professor Lineu Prestes Avenue, Cidade Universitária, São Paulo, SP, Brazil

3 PhD, Professor, Department of Oral Pathology, School of Dentistry, University of São Paulo, 2227 Professor Lineu Prestes Avenue, Cidade Universitária, São Paulo, SP, Brazil

4 DDS, Morumbi Education Institute (IME), St. Ministro Nélson Hungria, 238, Vila Tramontino/Real Parque, São Paulo, Brazil

Address correspondence to:

Lucyene Miguita

Department of Pathology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6.627, Pampulha, Belo Horizonte, MG 31270-901,

Brazil

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Article ID: 100032Z07LM2020

doi: 10.5348/100032Z07LM2020CR

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How to cite this article

Miguita L, Pina PSS, Pinto Junior DS, Santos BP, de Sousa SCOM. Low-grade intraductal carcinoma of the lower lip. J Case Rep Images Dent 2020;6:100032Z07LM2020.

ABSTRACT


Introduction: Low-grade intraductal carcinoma (LGIC) is a rare neoplasm of the salivary glands, composed of a single or multiple cystic space with intraductal or intracystic proliferation of neoplastic epithelial cells. It involves predominantly parotid glands and rarely occurs in minor salivary glands. Presently, a case of LGIC in an uncommon location is reported and compared with the clinical, histopathological, and immunohistochemical findings of other cases reported in minor salivary glands.

Case Report: A 53-year-old male patient reported with swelling in lower lip since four months. Histological findings showed neoplastic cells lining a large cystic space presenting intracystic proliferation formed by epithelial luminal cells, and sometimes a cribriform aspect. Neoplastic cells were positive for CK7 and S100 protein, and a rim of outer cells were p63 and S100 positive. Ki67 index was below 5%. The patient underwent surgical excision. One year later the patient is free of disease.

Conclusion: The present case report adds information pertinent to document a rare salivary gland tumor located in an unusual site, being the present one the fifth reported case of a LGIC, in the English literature, arising from minor salivary glands and the first reported in the lower lip.

Keywords: Carcinoma, Intraductal, Lip, Minor, Salivary glands

SUPPORTING INFORMATION


Author Contributions:

Lucyene Miguita - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Paulo Sérgio Souza Pina - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Final approval of the version to be published

Décio dos Santos Pinto Junior - Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published

Bruna Parrillo Santos - Acquisition of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published

Suzana Cantanhede Orsini Machado de Sousa - Substantial contributions to conception and design, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published

Acknowledgments

The authors would like to thank Juvani Lago Saturno for technical support.

Guaranter of Submission

The corresponding author is the guarantor of submission.

Source of Support

None

Consent Statement

Written informed consent was obtained from the patient for publication of this article.

Data Availability

All relevant data are within the paper and its Supporting Information files.

Conflict of Interest

Authors declare no conflict of interest.

Copyright

© 2020 Lucyene Miguita et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.


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