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Case Report
Hormonal influence on adenomatoid odontogenic tumor: A case report in pregnancy
1 MDS Oral Medicine & Radiology, Mumbai, India
2 Associate Professor, Department of Oral Medicine & Radiology, Nair Hospital Dental College, Mumbai, India
3 Assistant Professor, Department of Oral Medicine & Radiology, Government Dental College & Hospital, Aurangabad, India
4 Postgraduate, Department of Oral Medicine & Radiology, Nair Hospital Dental College, Mumbai, India
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Shivani Singh
MDS Oral Medicine & Radiology, Mumbai,
India
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Article ID: 100050Z07SS2025
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Singh S, Vahanwala S, Malu P, Soni S. Hormonal influence on adenomatoid odontogenic tumor: A case report in pregnancy. J Case Rep Images Dent 2025;11(1):11–17.ABSTRACT
Introduction: Pregnancy is a delicate physiologic state accompanied by increased risk of pathologic exposure. Oral complications like gingival enlargements, epulis, etc. are commonly seen in pregnant women owing to immune and hormonal changes. Although very few cases of odontogenic tumors have been reported, many authors have reported major estrogen-dependent tumors presumed to arise due to differences in genetic expression. Similarly, the influence of hormones in the growth of odontogenic tumors is also postulated. The correlation of certain proteins and receptors is being reviewed to understand the pathophysiology of potential interactions between hormones and odontogenic tumor cells. The literature search was conducted with the aim to derive a vivid explanation by identifying a common component between pregnancy and the occurrence of head and neck tumors.
Case Report: A report of patient in third trimester of pregnancy presenting with an odontogenic tumor, followed by a review of the possible relation between hormone and occurrence of odontogenic tumors in pregnant women.
Conclusion: Understanding the relationship between hormonal levels in females and the occurrence of jaw tumors will emphasize on importance of screening and follow-up of oral cavity in pregnant population and appropriate referral to a specialist, if necessary.
Keywords: Adenomatoid odontogenic tumor, Bcl-2, Estrogen receptor, Odontogenic tumor, Pregnancy
SUPPORTING INFORMATION
Author Contributions:
Shivani Singh - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Sonal Pratapsingh Vahanwala - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Pooja Malu - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Sakshi Soni - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Shivani Singh et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
